Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonistsZHIQIANG GUO; ZHU, Yun-Fei; QIU XIE et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 5, pp 1259-1271, issn 0022-2623, 13 p.Article

Non-Peptide Gonadotropin-Releasing Hormone Receptor AntagonistsBETZ, Stephen F; ZHU, Yun-Fei; CHEN CHEN et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 12, pp 3331-3348, issn 0022-2623, 18 p.Article

Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptorBETZ, Stephen F; REINHART, Greg J; LIO, Francisco M et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 2, pp 637-647, issn 0022-2623, 11 p.Article

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activityCHEN CHEN; YONGSHENG CHEN; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3301-3305, issn 0960-894X, 5 p.Article

Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5ROWBOTTOM, Martin W; TUCCI, Fabio C; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 19, pp 4967-4973, issn 0960-894X, 7 p.Article

Identification of 1-arylmethyl-3-(2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonistsZHU, Yun-Fei; GROSS, Timothy D; BONNEVILLE, Anne L et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 11, pp 2023-2026, issn 0022-2623, 4 p.Article

A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonistsTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 23, pp 3491-3495, issn 0960-894X, 5 p.Article

Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonistsMI CHEN; ZHIQIANG GUO; BRADBURY, Margaret J et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 14, pp 3845-3850, issn 0960-894X, 6 p.Article

Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902STRUTHERS, R. Scott; QUI XIE; MAKI, Richard A et al.Endocrinology (Philadelphia). 2007, Vol 148, Num 2, pp 857-867, issn 0013-7227, 11 p.Article

Suppression of serum luteinizing hormone in postmenopausal women by an orally administered nonpeptide antagonist of the gonadotropin-releasing hormone receptor (NBI-42902)STRUTHERS, R. Scott; CHEN, Takung; CAMPBELL, Bruce et al.The Journal of clinical endocrinology and metabolism. 2006, Vol 91, Num 10, pp 3903-3907, issn 0021-972X, 5 p.Article

Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH receptorTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 19, pp 3317-3322, issn 0960-894X, 6 p.Article

Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonistsWILCOXEN, Keith M; ZHU, Yun-Fei; CONNORS, Patrick J et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 16, pp 2179-2183, issn 0960-894XArticle

Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist ElagolixSTRUTHERS, R. Scott; NICHOLLS, Andrew J; GRUNDY, John et al.The Journal of clinical endocrinology and metabolism. 2009, Vol 94, Num 2, pp 545-551, issn 0021-972X, 7 p.Article

5-Aryluracils as potent GnRH antagonists : Characterization of atropisomersLIREN ZHAO; ZHIQIANG GUO; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3344-3349, issn 0960-894X, 6 p.Article

Discovery of Sodium R-(+)-4-{2 [5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1 -yl] -1 -phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorCHEN CHEN; DONGPEI WU; YONGSHENG CHEN et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 23, pp 7478-7485, issn 0022-2623, 8 p.Article

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonistsROWBOTTOM, Martin W; TUCCI, Fabio C; ZHU, Yun-Fei et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 9, pp 2269-2274, issn 0960-894X, 6 p.Article

Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical propertiesREGAN, Colin F; ZHIQIANG GUO; BROWN, Michael S et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 16, pp 4503-4507, issn 0960-894X, 5 p.Article

Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor : Implications for structure-activity relationships and insurmountable antagonismSULLIVAN, Susan K; HOARE, Sam R. J; FLECK, Beth A et al.Biochemical pharmacology. 2006, Vol 72, Num 7, pp 838-849, issn 0006-2952, 12 p.Article

Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modelingBETZ, Stephen F; LIO, Francisco M; YINGHONG GAO et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 21, pp 6170-6176, issn 0022-2623, 7 p.Article

3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl) -6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterizationTUCCI, Fabio C; ZHU, Yun-Fei; REINHART, Greg J et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 4, pp 1169-1178, issn 0022-2623, 10 p.Article

3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-ur acils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptorTUCCI, Fabio C; ZHU, Yun-Fei; TA KUNG CHEN et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 14, pp 3483-3486, issn 0022-2623, 4 p.Article

Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonistsZHIQIANG GUO; ZHU, Yun-Fei; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 19, pp 3311-3315, issn 0960-894X, 5 p.Article

A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonistsZHIQIANG GUO; DONGPEI WU; ZHU, Yun-Fei et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 3, pp 693-698, issn 0960-894X, 6 p.Article

Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonistsZHIQIANG GUO; DONGPEI WU; SAID, Yang et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 16, pp 3685-3690, issn 0960-894X, 6 p.Article

Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1, 2-a]pyrimid-5-ones as potent GnRH receptor antagonistsZHU, Yun-Fei; ZHIQIANG GUO; SAUNDERS, John et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 9, pp 1769-1772, issn 0022-2623, 4 p.Article